Ovarian hydatid cyst - systematic review of clinicopathological and immunohistochemical characteristics of an unusual entity Ludmila Lozneanu, Raluca Anca Balan, Simona Eliza Giusca, Irina-Draga Caruntu, Cornelia Amalinei, Adriana Grigoras Primary ovarian hydatid disease HD is a rare entity, produced by the larval stage of Echinococcus granulosus.
HD commonly involves liver, lung, abdomen cavity, spleen and is unusually identified in pelvic organs. Based on our knowledge, the paper reviews 27 literature reports of ovarian HD, diagnosed during the last 20 years, providing a valuable database. Patients ages ranged between years, the gross appearance was that of mm diameter hydatid cysts HCs According to these reports, ovarian HD has non-specific clinical manifestations, such as abdominal or pelvic pain, nausea, dysmenorrhea or amenorrhea.
Ovarian HC microscopic pattern is characterized by three layers: pericyst or adventitia host origingerminal layer endocystand laminated membrane ectocyst. The immunoreaction triggered by parasites is initially rich in macrophages and neutrophils, followed by eosinophils and lymphocytes, with numerous cluster of differentiation 8 CD8 -positive T-cells in active lesions and progressive forms.
In conclusion, the ovarian location of HD should be considered in any differential diagnosis of a cystic lesion, while it does not exclude synchronous ovarian tumors.
These cases reinforce the necessity of better measures of prophylaxis and screening of HD in endemic areas. The most common entities are gliomas, craniopharyngiomas and embryonal tumors, including primitive neuroectodermal tumors of the CNS, such as medulloblastoma.
Ovarian cancer young age stories. PLOS ONE: Romania
Proper management of malignancies requires a histological diagnosis, especially in childhood, since diagnostic errors have a significant negative influence on the treatment and subsequently on the patient s care. Experimental research conducted in the last years regarding the genomic and epigenetic landscape of pediatric brain tumors has provided considerable help in understanding their pathogenesis. New mutations and new signaling pathways have been associated with pediatric neoplasia, according to recent studies.
Current therapeutic protocols recommend triple therapy, consisting in the surgical resection of the tumor, radiotherapy and chemotherapy. Although immunotherapy and gene therapy continue to be a challenge, extensive studies are needed in order to confirm their promising role in the management of pediatric brain tumors.
If incidence trends continue, the annual number of HPV-positive oropharyngeal cancers is expected to overcome the annual number of cervical cancers by the yearin the US.
Aim: The aim of this paper is to review the recent data about several topics including risk factors of HPV-positive OPSCCs, guidelines in diagnostic evaluation, treatment, prognosis and prevention strategies, through prophylactic HPV vaccine on both sexes. Nowadays, HPV detection is a clinical standard of care for oropharyngeal malignancy by reporting tumors as HPV positive or p16 positive.
The extremely rare concha of Zuckerkandl reviewed and reported Mugurel Constantin Rusu, Mihai Sandulescu, Carmen Aurelia Mogoanta, Adelina Maria Jianu Background: Usual descriptions indicate three or maximum four nasal turbinates conchae attached to the lateral nasal wall. The middle, superior and, occasionally, supreme ones belong to the ethmoid bone. Few authors include in descriptions the concha that Zuckerkandl described as the fourth or supreme ethmoidal turbinate.
Despite some inconsistencies in Zuckerkandl s description, the concha bearing his name lies above Santorini s supreme concha, which, in turn, is above Morgagni s superior concha.
Ovarian cancer patient stories
Few other authors preferred to name Santorini s concha as the first supreme one and Zuckerkandl s concha as the second supreme one. Methods: We retrospectively documented, with various purposes, the archived cone-beam computed tomography files of patients.
Results: We found in just one case a unilateral sequence of five nasal turbinates. On the opposite side, only four turbinates were detected. Three-dimensional renderizations confirmed that when two supreme turbinates are found, they are joined in a common posterior tail, which, in turn, joins the tail of the superior turbinate. Conclusions: Co-existence of two supreme conchae could either indicate their origin from different ethmoturbinals, or from the split of a commonly unique supreme one.
Zuckerkandl s concha deserves therefore to be considered when anatomical descriptions, or studies, are delivered.
Systemic lupus erythematosus SLE is the prototype of connective tissue diseases that can present the complete spectrum of neurological and psychiatric dysfunctions.
The precise etiological diagnosis of neuropsychiatric systemic lupus erythematosus NPSLE is rather difficult to be established and it is still controversial the exact timing of neuropsychiatric NPS events: either central nervous system CNS is the initial target of autoimmune abnormalities, either NPS symptoms are a part of multisystem involvement. Neuroinflammation, consequent to blood-brain barrier BBB damage, local and systemic production of autoantibodies, determine neuronal injury and apoptosis, further responsible for diffuse cerebral events, mostly cognitive dysfunction and psychotic disorder.
Moreover, SLE complications or therapy complications can interfere and contribute to complex clinical manifestations that can be present in SLE patients.
Understanding the role of each pathogenic way can provide not only an early diagnosis, but ovarian cancer young age stories more accurate therapeutic approach of these patients. Toxicity and health impact of nanoparticles. In search of new therapeutic strategies for the ischemic brain, cell-based therapies offered new hope, which has been, in the meanwhile, converted into a more realistic approach recognizing difficulties related to unfavorable environments causing low survival rates of transplanted neuronal precursors.
Stem cell therapies are based on the transplantation of neuronal precursor cells NPCsadult stem cells propagated in cell culture or inducible pluripotent cells iPSCs obtained from patients and trans-differentiated into neural cells. Of these, autologous iPSCs have the advantage to be used in stroke patients because they do not raise ethical concerns and the risk of graft rejection is low.
However, the use of stem cells for stroke therapy in humans has to take into ovarian cancer young age stories ovarian cancer young age stories factors including, dosage, route of administration, toxicity and side effects.
For example, nanoparticles NPs may increase the efficacy of ovarian cancer young age stories and therapeutic cells delivery to the diseased brain. Medication dosages are generally determined by clinical trials done in relatively young, healthy people.
Delivering cancer treatment on a nanodisc helps eliminate tumors
However, in vivo and clinical data evaluating the toxic effects of NPs on neural cells are still scarce papiloamele si parazitii in the aged brain, which has a decreased homeostatic capacity and a reduced ability to cope with internal and environmental stress, as compared to the young brain.
Previous studies in rodents indicate that aging along with neurodegenerative diseases may promote a proinflammatory state and leads to the development of gliosis in the aged brains. On the other hand, the nonspecific interaction between the shell of NPs and brain proteins leads to the adsorption of opsonins on their surface, forming the so-called corona, thereby becoming ideal candidates to attract phagocytic microglia resulting in NPs engulfment and thus exacerbating neuronal death.
Therefore, when designing NPs for clinical use, it should be considered that their systemic administration is associated with potential ovarian cancer young age stories, especially in the aged subjects.
Recently, NPs have been shown in recent years to play a crucial role in cell signaling processes involved in stroke recovery. Extracellular vesicles EVs are secreted by virtually all type of cells in the body and have been shown to reflect the physiological and metabolic status of the host cells. Thus, understanding the disease-specific contents of EVs would enable the discovery of novel predictive biomarkers.
Basic biology and clinical perspective PDF 7. The complex biological mechanisms occurring in hypertrophic cancer benign de prostata are still barely understood. To date, there is no satisfactory description of ovarian cancer young age stories fibroblasts.
Therefore, in the present study we focused on the comparatively characterization of the fibroblasts residing in different regions of hypertrophic scars. These cell populations were further were used for the evaluation of proliferation and migration capacity, for the gene and protein expression of extracellular matrix protein type I collagen and fibronectin and for the presence of myofibroblasts.
Our results demonstrated that perilesional and intralesional fibroblasts isolated from hypertrophic scars could be considered as distinct leacul natural al viermilor, having different properties. Thus, the intralesional fibroblasts had an increased proliferation capacity and increased gene and protein expression of collagen I and fibronectin. However, the perilesional fibroblasts had augmented mobility as revealed by in vitro scratch test and contained a higher percentage of myofibroblasts [alpha-smooth muscle actin alpha-SMA high cells], in comparison to the intralesional population.
In conclusion, our data could provide an explanation regarding the inconsistent efficacy of topic therapies for hypertrophic scars. Among classical pancreatic markers that ascertain the histopathology, new emerging targets have been proposed for both diagnostic and prognostic purposes. SMAD4 showed an overall increase in tumors versus pancreatic control tissue, but a decrease from G1 towards poorly differentiated tumors, while TGFbetaR2, vimentin and CD showed higher expression values in the tumor areas.
Vimentin-CD colocalization degree decreased in tumor tissues compared to controls, illustrating a desynchronization of these two markers, both of them being negative in the tumor epithelia. Altogether, it is highly plausible that all these key players revolve around the epithelial-to-mesenchymal transition phenomenon, and this itself modulates the clinical outcome of the patient.
The etiology varies, and is often a multi-factor issue; what may contribute to gingival enlargement are aspects, such as disease, local and systemic conditions and idiopathic factors. The aim of the present study is to analyze and to correlate the clinical, epidemiological, imaging and histopathological HP features of gingival overgrowth in northeastern Romanian population. Patients, Materials and Methods: We conducted a clinical, imaging, and pathological study on 98 patients with gingival overgrowth, who underwent a surgical intervention for a gingival biopsy in the Office of Oral and Maxillofacial Surgery, Prof.
All patients with localized gingival overgrowth had clinical and imaging investigations done and then were referred to an oral and maxillofacial facility. A surgeon performed the excision of the gingival overgrowth and then sent the surgical specimens to the Laboratory of Pathology for HP examination. Results: Local inflammation was found responsible for the gingival overgrowth in most of the cases, with the number of females outnumbering that of the males.
- Singurele metode de tratament disponibile la momentul actual pentru această patologie sunt chimioterapia sistemică caracter paliativ şi chirurgia citoreductivă CR asociată cu chimioterapie ovarian cancer young age stories ovarian cancer young age stories HIPEC.
- Ovarian cancer patient stories, Hpv warts stories
- Save Diana Manea Altchek's Diagnosis and Management of Ovarian Disorders Deşi, de obicei, cancerul la sân afectează femeile, acesta poate apărea şi la bărbaţi, chiar dacă incidenţa este foarte rară la aceştia din urmă.
- Medicamente de helmint pentru copii
- Cancer ovarian gradul 4.
A very good correlation was found between clinical and HP diagnosis when epithelial hyperplasia, peripheral giant cell granuloma and pyogenic granuloma were involved and a moderate one when fibrous hyperplasia was involved. Conclusions: These findings suggest that the occurrence of gingival overgrowth can have many causes, which highlights the importance of clinical pathology in assisting practitioners with making a better diagnosis.
Endometrial cancer at young age
One of the fiercest complications after stroke is edema, which results from imbalanced water diffusion around the blood vessels walls. Water diffusion around blood vessel walls occurs physiologically mainly through two protein-formed pores, namely aquaporins AQPs 1 and 4.
Here, we compare for the first time the expression patterns and colocalization degrees of the two AQPs in control brain tissue and in peri-ischemic regions, on tissue obtained from eight patients with confirmed ischemic pathology and from five control cases.
The colocalization of the two markers was high, both located on the astrocytes membranes, but ovarian cancer young age stories colocalization degree decreased in the scar peri-ischemic regions. Ce numesc viermii lungi? fractures of humerus ovarian cancer young age stories children.
The most common benign bone tumors that cause pathological fractures in children are simple bone cysts, aneurysmal bone cysts, non-ossifying fibromas and fibrous dysplasia. This type of bone tumors is usually asymptomatic until they reach a large size and cause a pathological fracture after minor trauma. The optimal treatment remains controversial. Our objective was to describe our modern treatment strategies of the large benign osseous tumors of the humerus complicated by pathological humerus fractures and histological aspects in these cases.
Patients, Materials and Methods: The study was prospective and included patients who were diagnosed with pathological humeral fractures, which required surgically orthopedic treatment. We selected three cases of pathological fractures of humerus in children each with its particularities, treated in the Department of Pediatric Surgery and Orthopedics, Emergency County Hospital, Arad, Romania. Treatment included curettage of the cyst, sampling cum să distingem condiloamele histopathological HP examination, bone substitution and titanium elastic nails TEN osteosynthesis.
Results: No complications and no recurrence were seen in the early postoperative period.
Conclusions: Osteosynthesis with TEN and bone substitution is a viable option for treatment of pathological fracture of humerus, secondary to the osseous benign tumors, which required surgically treatment, despite the different HP ovarian cancer young age stories.
By using a combined treatment in these cases, we eliminate the disadvantages of isolated use of the described techniques in the literature. Therapeutic and pathological considerations PDF The statistical analysis was performed using the Student s t-test.
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More than half of the cases of mucinous ADK revealed an increased intensity of TB, whereas in the case of signet ring cell ADK, an average intensity of this phenomenon. There was a predominance of TB intensity in the absence of vascular-lymphatic invasion.
Our study shows the existence of a concordance between tumor progression, the histological type of CRC, vascular-lymphatic invasion and the phenomenon of TB. The aim of this study was to evaluate the long-term oncological outcome and survival rate in patients with early and locally advanced stages that underwent ISR, as compared to APR.